Furlani E P, Sahoo Y, Ng K C, Wortman J C, Monk T E
Institute for Lasers, Photonics and Biophotonics, University at Buffalo (SUNY), Buffalo, NY 14260, USA.
Biomed Microdevices. 2007 Aug;9(4):451-63. doi: 10.1007/s10544-007-9050-x.
A model is presented for predicting the capture of magnetic micro/nano-particles in a bioseparation microsystem. This bioseparator consists of an array of conductive elements embedded beneath a rectangular microfluidic channel. The magnetic particles are introduced into the microchannel in solution, and are attracted and held by the magnetic force produced by the energized elements. Analytical expressions are obtained for the dominant magnetic and fluidic forces on the particles as they move through the microchannel. These expressions are included in the equations of motion, which are solved numerically to predict particle trajectories and capture time. This model is well-suited for parametric analysis of particle capture taking into account variations in particle size, material properties, applied current, microchannel dimensions, fluid properties, and flow velocity.
提出了一种用于预测生物分离微系统中磁性微/纳米颗粒捕获情况的模型。该生物分离器由嵌入矩形微流体通道下方的一系列导电元件组成。磁性颗粒在溶液中被引入微通道，并被通电元件产生的磁力吸引并固定。得到了颗粒在微通道中移动时主要磁力和流体力的解析表达式。这些表达式包含在运动方程中，通过数值求解来预测颗粒轨迹和捕获时间。该模型非常适合考虑颗粒尺寸、材料特性、施加电流、微通道尺寸、流体特性和流速变化的颗粒捕获参数分析。
