Mueller Ruediger B, Sheriff Ahmed, Gaipl Udo S, Wesselborg Sebastian, Lauber Kirsten
Department of Internal Medicine 3, Institute of Clinical Immunology and Rheumatology, University Hospital Erlangen, Erlangen, Germany.
Autoimmunity. 2007 Jun;40(4):342-4. doi: 10.1080/08916930701356911.
Apoptotic cells promote the phagocytosis of themselves via the exposure of "eat me" signals. Furthermore, a second, "find me" signal is required to attract phagocytes. In this review the double function of lysophosphatidylcholine for the clearance of apoptotic material as factor leading to attraction of phagocytes as a soluble "find me" signal and opsonisation of apoptotic cells as a membrane bound "eat me" signal is outlined. Lysophosphatidylcholine, exerting this bivalent function, leads to a sufficient clearance of apoptotic cell as a "keep calm" mechanism to prevent activation of the immune system by secondary necrosis.
凋亡细胞通过暴露“吃我”信号来促进自身的吞噬作用。此外，还需要第二种“找到我”信号来吸引吞噬细胞。在这篇综述中，概述了溶血磷脂酰胆碱在清除凋亡物质方面的双重功能，它作为一种可溶性“找到我”信号导致吞噬细胞的吸引，同时作为一种膜结合“吃我”信号对凋亡细胞进行调理作用。溶血磷脂酰胆碱发挥这种二价功能，作为一种“保持冷静”的机制，通过防止继发坏死激活免疫系统，从而实现对凋亡细胞的充分清除。
