Sáenz-Francés F, Calvo-González C, Reche-Frutos J, Donate-López J, Huelga-Zapico E, García-Sánchez J, García-Feijoó J
Servicio de Oftalmología, Hospital Clínico Universitario San Carlos, Madrid, España.
Arch Soc Esp Oftalmol. 2007 May;82(5):303-6. doi: 10.4321/s0365-66912007000500010.
We present the case of a 65-year-old man who was seen in the casualty department complaining of bilateral visual loss. His past medical history was unremarkable except for chronic lymphocytic leukaemia diagnosed two years previously: he was no longer receiving treatment for this disorder. His visual acuity was 20/200 in the right eye and 20/63 in the left eye and he had a bilateral papilledema. Computed tomography and magnetic resonance imaging of the brain and orbit were performed and showed an infiltrative mass in the orbit with extension to the ethmoid bone and both optic nerves. Biopsy of the mass was compatible with chronic lymphocytic leukaemia.
Leukaemic infiltration of the optic nerve and central nervous system is a rare complication of chronic lymphocytic leukaemia, although it is common in the acute forms of this disease. Optic nerve infiltration is the most important ophthalmologic manifestation of leukaemia because it threatens vision and it is treatable.
