经视神经鞘活检证实的慢性淋巴细胞白血病所致视神经病变
Optic Neuropathy Due to Chronic Lymphocytic Leukemia Proven With Optic Nerve Sheath Biopsy.
作者信息
Khan Khurrum, Malik Amina I, Almarzouqi Sumayya J, Morgan Michael L, Yalamanchili Sushma, Chevez-Barrios Patricia, Lee Andrew G
机构信息
Baylor College of Medicine (KK, AGL), Houston, Texas; Department of Ophthalmology (AIM, SJA, MLM, SY, PC-B, AGL), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medical College, Houston, Texas; Department of Ophthalmology and Visual Sciences (AGL), The University of Texas Medical Branch, Galveston, Texas; The University of Texas MD Anderson Cancer Center (AGL), Houston, Texas; The University of Iowa Hospitals and Clinics (AGL), Iowa City, Iowa.
出版信息
J Neuroophthalmol. 2016 Mar;36(1):61-6. doi: 10.1097/WNO.0000000000000300.
Central nervous system involvement from chronic lymphocytic leukemia (CLL) occurs infrequently, and manifestations include cognitive and cerebellar dysfunction and cranial nerve palsies. We report a 45-year-old man with CLL believed to be in clinical remission, who presented with vision loss and bilateral optic disc edema. His optic neuropathy due to CLL was proven by optic nerve sheath biopsy, and he experienced visual recovery after treatment with ibrutinib and intrathecal methotrexate.
慢性淋巴细胞白血病（CLL）累及中枢神经系统的情况并不常见，其表现包括认知和小脑功能障碍以及颅神经麻痹。我们报告了一名45岁的CLL男性患者，据信处于临床缓解期，他出现了视力丧失和双侧视盘水肿。经视神经鞘活检证实其视神经病变由CLL引起，在接受依鲁替尼和鞘内注射甲氨蝶呤治疗后，他的视力得到了恢复。
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