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西多福韦和膦甲酸钠治疗一名中性粒细胞减少的干细胞移植受者的人疱疹病毒6型脑炎

Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient.

作者信息

Pöhlmann Christoph, Schetelig Johannes, Reuner Ulrike, Bornhäuser Martin, Illmer Thomas, Kiani Alexander, Ehninger Gerhard, Jacobs Enno, Rohayem Jacques

机构信息

Institut für Medizinische Mikrobiologie und Hygiene, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.

出版信息

Clin Infect Dis. 2007 Jun 15;44(12):e118-20. doi: 10.1086/518282. Epub 2007 May 2.

DOI:10.1086/518282
PMID:17516391
Abstract

We report a stem cell transplant recipient who developed human herpesvirus 6 encephalitis. Human herpesvirus 6 load indicated massive intrathecal viral replication. Administration of cidofovir followed by foscarnet was associated with total clearance of human herpesvirus 6 infection. Cidofovir and foscarnet combination therapy may be beneficial for reducing mortality of (neutropenic) stem cell transplant recipients with human herpesvirus 6 encephalitis.

摘要

我们报告了一名发生人疱疹病毒6型脑炎的干细胞移植受者。人疱疹病毒6型载量表明存在大量鞘内病毒复制。给予西多福韦随后给予膦甲酸钠与清除人疱疹病毒6型感染相关。西多福韦和膦甲酸钠联合治疗可能有助于降低患人疱疹病毒6型脑炎的（中性粒细胞减少的）干细胞移植受者的死亡率。

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