匈牙利非甲、非乙、非丙型肝炎患者中戊型肝炎病毒的血清流行病学研究。

Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary.

作者信息

Haagsman Annika, Reuter Gábor, Duizer Erwin, Nagy Gyuláné, Herremans Tineke, Koopmans Marion, Szücs György

机构信息

Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

出版信息

J Med Virol. 2007 Jul;79(7):927-30. doi: 10.1002/jmv.20869.

DOI:10.1002/jmv.20869

PMID:17516521

Abstract

Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5% of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9% had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1% of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1% of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV IgG and/or IgM tested negative for HEV RNA by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis E should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis.

摘要

许多急性肝炎病例仍未得到诊断，戊型肝炎病毒（HEV）在工业化国家中日益凸显。本研究旨在评估HEV在匈牙利急性非甲、非乙、非丙型肝炎患者中作为病原体的作用。通过酶联免疫吸附测定（ELISA）检测，264例急性非甲、非乙、非丙型肝炎患者中有10.5%抗HEV IgG呈阳性，1.9%抗HEV IgM呈阳性。经蛋白质印迹法确认后，6.1%的急性非甲、非乙、非丙型肝炎患者仅抗HEV IgG抗体呈阳性，1.1%的患者IgG和IgM均呈阳性。所有19例抗HEV IgG和/或IgM呈阳性的患者经聚合酶链反应（PCR）检测HEV RNA均为阴性。匈牙利西南部只有一小部分急性肝炎病例被认为归因于HEV感染，然而，在急性肝炎的诊断中，应将戊型肝炎与甲型、乙型和丙型肝炎一并考虑。