Freitas Nara Rubia de, Santana Edna Braz Rocha de, Silva Ágabo Macedo da Costa E, Silva Sueli Meira da, Teles Sheila Araújo, Gardinali Noemi Rovaris, Pinto Marcelo Alves, Martins Regina Maria Bringel
Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, GO, Brasil.
Universidade Federal de Goiás, Faculdade de Enfermagem, Goiânia, GO, Brasil.
Mem Inst Oswaldo Cruz. 2016 Nov;111(11):692-696. doi: 10.1590/0074-02760160256. Epub 2016 Oct 13.
Hepatitis E virus (HEV) infection has a worldwide distribution and represents an important cause of acute hepatitis. This study aims to investigate the occurrence of HEV infection and factors associated with this infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil. From April 2012 to October 2014, a cross-sectional study was conducted among 379 patients with acute non-A, non-B, non-C hepatitis in the City of Goiania, Central Brazil. Serum samples of all patients were tested for serological markers of HEV infection (anti-HEV IgM and IgG) by ELISA. Positive samples were confirmed using immunoblot test. Anti-HEV IgM and IgG positive samples were tested for HEV RNA. Of the 379 serum samples, one (0.3%) and 20 (5.3%) were positive for anti-HEV IgM and IgG, respectively. HEV RNA was not found in any sample positive for IgM and/or IgG anti-HEV. After multivariate analysis, low education level was independently associated with HEV seropositivity (p = 0.005), as well as living in rural area, with a borderline p-value (p = 0.056). In conclusion, HEV may be responsible for sporadic self-limited cases of acute hepatitis in Central Brazil.
戊型肝炎病毒（HEV）感染在全球范围内均有分布，是急性肝炎的一个重要病因。本研究旨在调查巴西中部急性非甲、非乙、非丙型肝炎患者中HEV感染的发生情况及其相关因素。2012年4月至2014年10月，在巴西中部戈亚尼亚市对379例急性非甲、非乙、非丙型肝炎患者进行了一项横断面研究。通过酶联免疫吸附测定法（ELISA）检测所有患者血清样本中的HEV感染血清学标志物（抗HEV IgM和IgG）。阳性样本采用免疫印迹试验进行确认。对抗HEV IgM和IgG阳性样本检测HEV RNA。在379份血清样本中，抗HEV IgM和IgG阳性的分别有1份（0.3%）和20份（5.3%）。在任何抗HEV IgM和/或IgG阳性样本中均未发现HEV RNA。多因素分析后，低教育水平与HEV血清学阳性独立相关（p = 0.005），居住在农村地区也与之相关，p值接近临界值（p = 0.056）。总之，在巴西中部，HEV可能是急性肝炎散发性自限性病例的病因。
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