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锯齿状腺瘤及其变体的组织病理学,以及与传统腺瘤性息肉和增生性息肉的鉴别。

Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps.

作者信息

Li Shuan C, Burgart Lawrence

机构信息

Department of Pathology and Laboratory Medicine, Orlando Regional Healthcare, 1414 Kuhl Ave, Orlando, FL 32806, USA.

出版信息

Arch Pathol Lab Med. 2007 Mar;131(3):440-5. doi: 10.5858/2007-131-440-HOSAIV.

DOI:10.5858/2007-131-440-HOSAIV
PMID:17516746
Abstract

CONTEXT

Serrated adenomas can be morphologically subdivided into traditional and sessile types. They are thought to have a comparable rate of cancer progression like conventional adenomas, but they potentially have a faster rate of growth through methylation pathway(s). They share similar morphologic features with both the conventional adenoma and the hyperplastic polyp in a fashion that is different from a mixed adenoma and a hyperplastic polyp.

OBJECTIVE

To describe the histopathologic features of traditional serrated adenoma and sessile serrated adenoma and their comparison with traditional adenomas and hyperplastic polyp.

DATA SOURCES

Relevant articles in peer-review journals and the authors' working experience as practicing surgical pathologists with a specific interest in gastrointestinal pathology.

CONCLUSIONS

Both types of serrated adenomas, traditional serrated adenoma and sessile serrated adenoma, are morphologically distinct, clinically important entities, and they can be diagnosed accurately in routine practice.

摘要

背景

锯齿状腺瘤在形态学上可细分为传统型和无蒂型。它们被认为与传统腺瘤具有相似的癌症进展率,但通过甲基化途径可能具有更快的生长速度。它们与传统腺瘤和增生性息肉具有相似的形态学特征,但其方式不同于混合性腺瘤和增生性息肉。

目的

描述传统锯齿状腺瘤和无蒂锯齿状腺瘤的组织病理学特征,并将它们与传统腺瘤和增生性息肉进行比较。

数据来源

同行评审期刊上的相关文章以及作者作为对胃肠道病理学有特殊兴趣的外科病理学家的工作经验。

结论

传统锯齿状腺瘤和无蒂锯齿状腺瘤这两种类型在形态学上都是独特的、具有临床重要性的实体,并且在常规实践中可以准确诊断。

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