慢性血液透析患者血清中游离轻链λ浓度升高。

Increased concentrations of free light chain lambda in sera from chronic hemodialysis patients.

作者信息

Wakasugi K, Sasaki M, Suzuki M, Azuma N, Nobuto T

机构信息

Department of Internal Medicine, Tokyo Medical College at Hachioji.

出版信息

Biomater Artif Cells Immobilization Biotechnol. 1991;19(1):97-109. doi: 10.3109/10731199109117819.

DOI:10.3109/10731199109117819

PMID:1751683

Abstract

Serum levels of FLc were determined in 5 pre-HD CRF patients, 63 CRF patients receiving HD therapy, 15 CAPD and 40 healthy volunteers. The highest serum FLc concentration was observed in patients receiving HD. Concentrations of kappa- and lambda FLc were higher than normal in patients with CRF, and were about 4-fold and 1.8 fold greater than control values in HD patients, with a predominance of lambda chains. This HD-associated elevation of serum FLc strongly suggests a role for FLc in the etiology of light chain deposit disease and AL-amyloidosis. Lambda-FLc and beta 2-m exhibited similar patterns of change in the serum during the course of HD therapy. Further studies may reveal other pathological conditions other than CRF in which these polypeptides may play a role.

摘要

对5例慢性肾衰竭（CRF）前期患者、63例接受血液透析（HD）治疗的CRF患者、15例持续性不卧床腹膜透析（CAPD）患者及40名健康志愿者测定了血清游离轻链（FLc）水平。接受HD治疗的患者血清FLc浓度最高。CRF患者的κ和λ FLc浓度高于正常水平，HD患者的κ和λ FLc浓度分别约为对照值的4倍和1.8倍，且以λ链为主。HD相关的血清FLc升高强烈提示FLc在轻链沉积病和AL淀粉样变性的病因学中起作用。在HD治疗过程中，λ-FLc和β2-微球蛋白（β2-m）在血清中的变化模式相似。进一步研究可能会揭示除CRF外这些多肽可能起作用的其他病理状况。