Wiederhold Nathan P, Lewis James S
University of Texas at Austin College of Pharmacy, TX, USA.
Expert Opin Pharmacother. 2007 Jun;8(8):1155-66. doi: 10.1517/14656566.8.8.1155.
Micafungin is a relatively broad-spectrum antifungal agent available for clinical use in the US and Japan. By inhibiting the production of beta-1,3-glucan, an essential fungal cell wall component, micafungin has reduced toxicity to mammalian cells while maintaining potent antifungal activity against many pathogenic fungi including polyene- and azole-resistant isolates. Indeed, micafungin has been shown to be efficacious in the treatment of infections caused by Candida and Aspergillus species in clinical trials without the associated toxicities of amphotericin B formulations and drug interactions that occur with the azoles. In this review, the pharmacology, spectrum of activity, clinical efficacy and safety profile of micafungin are discussed.
米卡芬净是一种相对广谱的抗真菌药物，在美国和日本可用于临床。通过抑制β-1,3-葡聚糖（一种重要的真菌细胞壁成分）的产生，米卡芬净降低了对哺乳动物细胞的毒性，同时对许多致病真菌，包括对多烯类和唑类耐药的菌株，保持了强大的抗真菌活性。事实上，在临床试验中，米卡芬净已被证明对治疗念珠菌和曲霉菌引起的感染有效，且没有两性霉素B制剂相关的毒性以及唑类药物出现的药物相互作用。在这篇综述中，将讨论米卡芬净的药理学、活性谱、临床疗效和安全性。
