Zhao Yanan, Prideaux Brendan, Baistrocchi Shane, Sheppard Donald C, Perlin David S
Public Health Research Institute, New Jersey Medical School-Rutgers Biomedical and Health Sciences, Newark, NJ 07103.
Departments of Medicine, Microbiology & Immunology, McGill University, Montreal, Quebec H4A 3J1.
Med Mycol. 2019 Apr 1;57(Supplement_2):S161-S167. doi: 10.1093/mmy/myy067.
Despite advances in antifungal therapy, invasive fungal infections remain a significant cause of morbidity and mortality worldwide. One important factor contributing to the relative ineffectiveness of existing antifungal drugs is insufficient drug exposure at the site of infection. Despite the importance of this aspect of antifungal therapy, we generally lack a full appreciation of how antifungal drugs distribute, penetrate, and interact with their target organisms in different tissue subcompartments. A better understanding of drug distribution will be critical to guide appropriate use of currently available antifungal drugs, as well as to aid development of new agents. Herein we briefly review current perspectives of antifungal drug exposure at the site of infection and describe a new technique, matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging, which has the potential to greatly expand our understanding of drug penetration.
尽管抗真菌治疗取得了进展，但侵袭性真菌感染仍然是全球发病和死亡的重要原因。现有抗真菌药物相对无效的一个重要因素是感染部位的药物暴露不足。尽管这是抗真菌治疗的一个重要方面，但我们通常对抗真菌药物在不同组织亚区室中如何分布、渗透以及与靶标生物体相互作用缺乏全面认识。更好地了解药物分布对于指导当前可用抗真菌药物的合理使用以及辅助新型药物的研发至关重要。在此，我们简要回顾目前关于感染部位抗真菌药物暴露的观点，并描述一种新技术——基质辅助激光解吸电离（MALDI）质谱成像，它有可能极大地扩展我们对药物渗透的理解。
