Hibel Leah C, Granger Douglas A, Cicchetti Dante, Rogosch Fred
The Pennsylvania State University, Unviersity Park, PA 16803, USA.
Child Dev. 2007 May-Jun;78(3):927-37. doi: 10.1111/j.1467-8624.2007.01041.x.
This study examined associations between medications prescribed to control children's problem behaviors and levels of, and diurnal variation in, salivary cortisol (C), testosterone (T), and dehydroepiandrosterone (DHEA). Saliva was collected in the morning, midday, and afternoon from 432 children ages 6-13 years. Relative to a no-medication comparison group, children taking (1) antipsychotics had higher DHEA levels and flat C diurnal rhythms, (2) Ritalin or Adderall had flat T diurnal rhythms, (3) Concerta had higher T and DHEA levels, (4) antidepressants had flat DHEA diurnal rhythms, and (5) hypotensives had flat DHEA diurnal rhythms and higher T levels. Medications prescribed to control children's problem behaviors should be monitored in studies of the endocrine correlates and consequences of developmental psychopathology.
本研究考察了用于控制儿童问题行为的药物与唾液皮质醇（C）、睾酮（T）和脱氢表雄酮（DHEA）水平及其昼夜变化之间的关联。从432名6至13岁儿童中收集早晨、中午和下午的唾液。与未用药的对照组相比，服用以下药物的儿童情况如下：（1）抗精神病药物的DHEA水平较高，C的昼夜节律平缓；（2）利他林或阿得拉的T昼夜节律平缓；（3）康奈达的T和DHEA水平较高；（4）抗抑郁药的DHEA昼夜节律平缓；（5）降压药的DHEA昼夜节律平缓且T水平较高。在发育性精神病理学的内分泌相关性及后果研究中，应对用于控制儿童问题行为的药物进行监测。
