产前烟草暴露与婴儿应激反应性：儿童性别和母亲行为的作用。
Prenatal tobacco exposure and infant stress reactivity: role of child sex and maternal behavior.
作者信息
Eiden Rina D, Molnar Danielle S, Granger Douglas A, Colder Craig R, Schuetze Pamela, Huestis Marilyn A
机构信息
Research Institute on Addictions, State University of New York at Buffalo, Buffalo, NY.
出版信息
Dev Psychobiol. 2015 Mar;57(2):212-25. doi: 10.1002/dev.21284. Epub 2015 Feb 3.
Abstract
This study examined the association between prenatal tobacco exposure (PTE) and infant cortisol reactivity at 9 months of infant age. Child sex and maternal parenting behavior were hypothesized moderators. The sample included 217 (148 tobacco-exposed, 69 non-exposed) mother-child dyads. Data used were obtained from pregnancy assessments, mother-infant feeding interactions at 2 months, and salivary cortisol at four time points in response to frustration at 9 months. Results indicated a significant association between PTE and infant cortisol that was moderated by infant sex and maternal intrusiveness. That is, PTE boys had lower cortisol than control boys, but there was no association between PTE and cortisol among girls. There was a significant association between PTE and cortisol among infants of intrusive mothers, but not among infants with non-intrusive mothers. Thus, PTE was associated with cortisol hypo-reactivity such that boys and non-exposed infants experiencing high maternal intrusiveness were at greater risk.
摘要
本研究考察了产前烟草暴露（PTE）与婴儿9个月大时的皮质醇反应性之间的关联。假设儿童性别和母亲的养育行为为调节因素。样本包括217对母婴二元组（148对有烟草暴露，69对无暴露）。所使用的数据来自孕期评估、2个月时的母婴喂养互动，以及9个月时四个时间点应对挫折时的唾液皮质醇。结果表明，PTE与婴儿皮质醇之间存在显著关联，且受婴儿性别和母亲侵扰性的调节。也就是说，暴露于烟草的男孩皮质醇水平低于对照组男孩，但女孩中PTE与皮质醇之间无关联。侵扰性母亲的婴儿中，PTE与皮质醇之间存在显著关联，但非侵扰性母亲的婴儿中则无此关联。因此，PTE与皮质醇低反应性相关，使得经历高母亲侵扰性的男孩和未暴露婴儿风险更大。
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