Goodyer I M, Herbert J, Altham P M, Pearson J, Secher S M, Shiers H M
Department of Psychiatry, University of Cambridge.
Psychol Med. 1996 Mar;26(2):245-56. doi: 10.1017/s0033291700034644.
The association between basal cortisol, dehydroepiandrosterone (DHEA), its sulphate (DHEAS) and major depression was investigated in 8- to 16-year-olds. Eighty-two subjects with major depression, 25 non-depressed psychiatric cases and 40 community controls were systematically assessed for current mental state and hormone levels at 08.00, 12.00 and 20.00 h, assayed from salivary samples collected over a 48 h period. The average mean of the two time points was compared between the three groups. Evening cortisol hypersecretion and morning DHEA hyposecretion were significantly, and independently, associated with major depression. High evening cortisol (> 0.594 ng/mL) and low morning DHEA (< 0.200 ng/mL) identified subgroups of depressives with different types of adrenal hormone dysregulation. The association between high evening cortisol or low morning DHEA and MDD was not affected by either age or gender.
研究了8至16岁儿童中基础皮质醇、脱氢表雄酮（DHEA）及其硫酸盐（DHEAS）与重度抑郁症之间的关联。对82例重度抑郁症患者、25例非抑郁精神病例和40名社区对照者在08:00、12:00和20:00对其当前精神状态和激素水平进行了系统评估，这些样本是在48小时内收集的唾液样本中检测的。比较了三组之间两个时间点的平均均值。夜间皮质醇分泌过多和早晨DHEA分泌过少与重度抑郁症显著且独立相关。高夜间皮质醇（>0.594 ng/mL）和低早晨DHEA（<0.200 ng/mL）确定了具有不同类型肾上腺激素失调的抑郁症亚组。高夜间皮质醇或低早晨DHEA与重度抑郁症之间的关联不受年龄或性别的影响。
