Kozicz Tamás
Department of Cellular Animal Physiology, Faculty of Science, Integrative Physiology, EURON European Graduate School of Neuroscience, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
Gen Comp Endocrinol. 2007 Aug-Sep;153(1-3):235-40. doi: 10.1016/j.ygcen.2007.04.005. Epub 2007 Apr 11.
The discovery of novel members of the CRF neuropeptide family, urocortin 1 (Ucn1), urocortin 2 and 3 has provided important insights into stress adaptation pathways, and predicted that stress adaptation involves more systems than the HPA-axis alone. This mini-review aims to summarize our recent data and research by others indicating that an important role is played by Ucn1 in the non-preganglionic Edinger-Westphal nucleus (npEW). These results point to an intriguing possibility that CRF/Ucn1 neuronal circuits comprise two separate, but functionally interrelated entities, which are coordinately regulated by acute stressors, but are inversely coupled during chronic stress. Such collaboration between the two systems would implicate a very important role of Ucn1 in adaptation to stress, and, as a consequence, in stress-related disorders like anxiety, major depression and use of drugs of abuse.
促肾上腺皮质激素释放因子（CRF）神经肽家族新成员——尿皮质素1（Ucn1）、尿皮质素2和尿皮质素3的发现，为应激适应途径提供了重要见解，并预测应激适应涉及的系统不止下丘脑-垂体-肾上腺（HPA）轴。这篇综述旨在总结我们最近的数据以及其他研究，这些表明Ucn1在非节前动眼神经副核（npEW）中发挥着重要作用。这些结果表明了一种有趣的可能性，即CRF/Ucn1神经回路由两个独立但功能相关的实体组成，它们在急性应激源作用下受到协同调节，但在慢性应激期间呈反向耦合。这两个系统之间的这种协作将意味着Ucn1在应激适应中发挥非常重要的作用，因此在焦虑、重度抑郁和药物滥用等应激相关疾病中也发挥重要作用。
