Cavézian Céline, Danckert James, Lerond Jérôme, Daléry Jean, d'Amato Thierry, Saoud Mohamed
Université de Lyon, Lyon, F-69003, France.
Brain Cogn. 2007 Aug;64(3):257-64. doi: 10.1016/j.bandc.2007.03.008. Epub 2007 May 22.
Previous studies have suggested a right hemineglect in schizophrenia, however few assessed possible visual-perceptual implication in this lateralized anomaly. A manual line bisection without (i.e., lines presented on their own) or with a local cueing paradigm (i.e., a number placed at one or both ends of the line) and the Motor-free Visual Perceptual Test-Vertical format (MVPT-V) were used to assess the visual-perceptual abilities of healthy controls, schizophrenia and depressed patients. Whereas healthy controls and depressed patients showed a non-significant leftward bias in manual line bisection, schizophrenia patients bisected significantly to the left of the true centre of the line. Interestingly, the pattern of performances in response to the local cueing paradigm was similar in depressed and schizophrenia patients such that both groups demonstrated a significant change in their bisection performance only in response to a cue placed at the right extremity of the line (control performance was modified by cues at either end of the line). Finally, in the MVPT-V, schizophrenia patients were impaired relative to the other two groups, especially in the spatial working memory and visual closure categories. These results suggest that: 1/a deficit towards the right hemifield, consistent with a mild form of right hemineglect, can be observed in schizophrenia; 2/lateralized anomalies could also be observed in depression using an appropriate tool such as manual line bisection; 3/performances in the MVPT-V suggested that a simple visual-perceptual deficit could not explain the lateralized anomaly observed in the manual line bisection, as it is the case in the hemineglect syndrome.
先前的研究表明精神分裂症患者存在右侧半侧忽视现象，然而很少有研究评估这种偏侧化异常可能的视觉感知影响。使用无局部提示范式（即单独呈现线条）或有局部提示范式（即在线条一端或两端放置一个数字）的手动直线二等分任务以及无运动视觉感知测试垂直版（MVPT-V）来评估健康对照者、精神分裂症患者和抑郁症患者的视觉感知能力。健康对照者和抑郁症患者在手动直线二等分任务中表现出不显著的向左偏差，而精神分裂症患者的二等分点明显在直线真正中心的左侧。有趣的是，抑郁症患者和精神分裂症患者对局部提示范式的表现模式相似，即两组仅在对位于线条右端的提示做出反应时，其二等分表现才出现显著变化（对照组的表现会因线条两端的提示而改变）。最后，在MVPT-V测试中，精神分裂症患者相对于其他两组存在受损情况，尤其是在空间工作记忆和视觉闭合类别方面。这些结果表明：1/在精神分裂症中可观察到对右侧半视野的缺陷，这与轻度形式的右侧半侧忽视一致；2/使用诸如手动直线二等分这样的合适工具，在抑郁症中也可观察到偏侧化异常；3/MVPT-V测试中的表现表明，简单的视觉感知缺陷无法解释在手动直线二等分任务中观察到的偏侧化异常，而在半侧忽视综合征中情况则不同。
