Lam Sik Lok
Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W713-7. doi: 10.1093/nar/gkm320. Epub 2007 May 21.
DSHIFT is a web server for predicting chemical shifts of DNA sequences in random coil form or double helical B-form. The prediction methods are based on sets of published reference chemical shift values and correction factors which account for shielding or deshielding effects from neighboring nucleotides. Proton, carbon and phosphorus chemical shift predictions are available for random coil DNAs. For double helical B-DNA, only proton chemical shift prediction is available. Results from these predictions will be useful for facilitating NMR resonance assignments and investigating structural features of solution DNA molecules. The URL of this server is: http://www.chem.cuhk.edu.hk/DSHIFT.
DSHIFT是一个用于预测随机卷曲形式或双螺旋B型DNA序列化学位移的网络服务器。预测方法基于已发表的参考化学位移值集和校正因子，这些校正因子考虑了相邻核苷酸的屏蔽或去屏蔽效应。对于随机卷曲的DNA，可以进行质子、碳和磷的化学位移预测。对于双螺旋B-DNA，仅提供质子化学位移预测。这些预测结果将有助于促进核磁共振共振归属和研究溶液中DNA分子的结构特征。该服务器的网址为：http://www.chem.cuhk.edu.hk/DSHIFT 。
