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An official ATS statement: hepatotoxicity of antituberculosis therapy.美国胸科学会官方声明：抗结核治疗的肝毒性
Am J Respir Crit Care Med. 2006 Oct 15;174(8):935-52. doi: 10.1164/rccm.200510-1666ST.
2
Association between acquired rifamycin resistance and the pharmacokinetics of rifabutin and isoniazid among patients with HIV and tuberculosis.HIV 合并结核病患者获得性利福霉素耐药性与利福布汀和异烟肼药代动力学之间的关联
Clin Infect Dis. 2005 May 15;40(10):1481-91. doi: 10.1086/429321. Epub 2005 Apr 14.
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The early bactericidal activities of rifampin and rifapentine in pulmonary tuberculosis.利福平与利福喷丁在肺结核中的早期杀菌活性
Am J Respir Crit Care Med. 2005 Jul 1;172(1):128-35. doi: 10.1164/rccm.200411-1557OC. Epub 2005 Apr 1.
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What is the 'right' dose of rifampin?利福平的“正确”剂量是多少？
Int J Tuberc Lung Dis. 2003 Jan;7(1):3-5.
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Therapeutic drug monitoring in the treatment of tuberculosis.结核病治疗中的治疗药物监测
Drugs. 2002;62(15):2169-83. doi: 10.2165/00003495-200262150-00001.
6
Low plasma concentrations of rifampicin in tuberculosis patients in Indonesia.印度尼西亚结核病患者中利福平的血浆浓度较低。
Int J Tuberc Lung Dis. 2002 Jun;6(6):497-502. doi: 10.5588/09640569513002.
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Role of individual drugs in the chemotherapy of tuberculosis.个别药物在结核病化疗中的作用。
Int J Tuberc Lung Dis. 2000 Sep;4(9):796-806.
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A multicentre study of the early bactericidal activity of anti-tuberculosis drugs.一项抗结核药物早期杀菌活性的多中心研究。
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The early bactericidal activity of rifabutin in patients with pulmonary tuberculosis measured by sputum viable counts: a new method of drug assessment.通过痰液活菌计数测定利福布汀在肺结核患者中的早期杀菌活性：一种新的药物评估方法。
J Antimicrob Chemother. 1993 Dec;32(6):867-75. doi: 10.1093/jac/32.6.867.
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[Antibiotic treatment of brucellosis].[布鲁氏菌病的抗生素治疗]
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痰涂片阳性的肺结核患者中高剂量利福平的早期杀菌活性

Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears.

作者信息

Diacon A H, Patientia R F, Venter A, van Helden P D, Smith P J, McIlleron H, Maritz J S, Donald P R

机构信息

Department of Internal Medicine, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa.

出版信息

Antimicrob Agents Chemother. 2007 Aug;51(8):2994-6. doi: 10.1128/AAC.01474-06. Epub 2007 May 21.

DOI:10.1128/AAC.01474-06
PMID:17517849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1932511/
Abstract

We studied the early bactericidal activity of twice the standard dose of rifampin in subjects with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day activity was almost double that reported at the standard dose. Further studies are warranted to establish whether higher rifampin doses might assist in shortening tuberculosis treatment.

摘要

我们研究了标准剂量两倍的利福平在痰涂片阳性的肺结核患者中的早期杀菌活性。观察到的平均2日活性几乎是标准剂量报道值的两倍。有必要进行进一步研究以确定更高剂量的利福平是否有助于缩短结核病治疗时间。