痰涂片阳性的肺结核患者中高剂量利福平的早期杀菌活性
Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears.
作者信息
Diacon A H, Patientia R F, Venter A, van Helden P D, Smith P J, McIlleron H, Maritz J S, Donald P R
机构信息
Department of Internal Medicine, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa.
出版信息
Antimicrob Agents Chemother. 2007 Aug;51(8):2994-6. doi: 10.1128/AAC.01474-06. Epub 2007 May 21.
Abstract
We studied the early bactericidal activity of twice the standard dose of rifampin in subjects with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day activity was almost double that reported at the standard dose. Further studies are warranted to establish whether higher rifampin doses might assist in shortening tuberculosis treatment.
摘要
我们研究了标准剂量两倍的利福平在痰涂片阳性的肺结核患者中的早期杀菌活性。观察到的平均2日活性几乎是标准剂量报道值的两倍。有必要进行进一步研究以确定更高剂量的利福平是否有助于缩短结核病治疗时间。
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