Locarnini S
Hepatitis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria, Australia.
J Gastroenterol Hepatol. 1991;6 Suppl 1:18-22. doi: 10.1111/j.1440-1746.1991.tb01161.x.
The effectiveness of therapies for chronic hepatitis B will depend on their ability to inhibit all HBV replicative intermediates including viral SC DNA as well as stimulating the host's immune system to clear virus and produce sustained immunity. Future therapies will require the use of combined treatments in 'cocktail-type arrangements' as outlined in this paper, linked with careful staging of the hepatitis B carrier state.
慢性乙型肝炎治疗方法的有效性将取决于其抑制包括病毒松弛环状DNA在内的所有乙肝病毒复制中间体的能力，以及刺激宿主免疫系统清除病毒并产生持久免疫力的能力。未来的治疗将需要采用本文所述的“鸡尾酒式组合”联合治疗方法，并结合对乙肝携带者状态的仔细分期。
