更昔洛韦与膦甲酸钠作为鸭乙型肝炎病毒体外复制抑制剂的相互作用。
Interaction between ganciclovir and foscarnet as inhibitors of duck hepatitis B virus replication in vitro.
作者信息
Civitico G, Shaw T, Locarnini S
机构信息
Victorian Infectious Diseases Reference Laboratory, Fairfield Hospital, Australia.
出版信息
Antimicrob Agents Chemother. 1996 May;40(5):1180-5. doi: 10.1128/AAC.40.5.1180.
Abstract
Safe and effective treatments for chronic hepatitis B virus (HBV) infection have yet to be developed. Both ganciclovir (9-[1,3-dihydroxy-2-propoxymethyl]guanine) and foscarnet (trisodium phosphonoformate hexahydrate) are potent inhibitors of hepadnavirus replication when used individually in vitro and in vivo. However, the clinical usefulness of each drug is reduced by dose-limiting toxicity, especially during long-term monotherapy. Here we demonstrate additive inhibition of duck HBV DNA replication in cultures of primary duck hepatocytes congenitally infected with duck HBV by combinations of ganciclovir and foscarnet at low, clinically achievable concentrations. These results suggest that the effects of ganciclovir and foscarnet against HBV may be additive in vivo.
摘要
针对慢性乙型肝炎病毒（HBV）感染的安全有效的治疗方法尚未研发出来。更昔洛韦（9-[1,3-二羟基-2-丙氧甲基]鸟嘌呤）和膦甲酸钠（六水合膦甲酸钠三钠）在体外和体内单独使用时都是乙肝病毒复制的有效抑制剂。然而，每种药物的临床效用都因剂量限制性毒性而降低，尤其是在长期单一疗法期间。在此，我们证明了在先天性感染鸭乙肝病毒的原代鸭肝细胞培养物中，更昔洛韦和膦甲酸钠以低的、临床可达到的浓度联合使用时，对鸭乙肝病毒DNA复制具有相加抑制作用。这些结果表明，更昔洛韦和膦甲酸钠对乙肝病毒的作用在体内可能是相加的。
相似文献
1
Interaction between ganciclovir and foscarnet as inhibitors of duck hepatitis B virus replication in vitro.更昔洛韦与膦甲酸钠作为鸭乙型肝炎病毒体外复制抑制剂的相互作用。
Antimicrob Agents Chemother. 1996 May;40(5):1180-5. doi: 10.1128/AAC.40.5.1180.
2
Long-term ganciclovir chemotherapy for congenital duck hepatitis B virus infection in vivo: effect on intrahepatic-viral DNA, RNA, and protein expression.长期更昔洛韦化疗对先天性鸭乙型肝炎病毒体内感染的影响：对肝内病毒DNA、RNA及蛋白质表达的作用
Hepatology. 1996 Oct;24(4):766-73. doi: 10.1053/jhep.1996.v24.pm0008855174.
3
Antiviral strategies in chronic hepatitis B virus infection: II. Inhibition of duck hepatitis B virus in vitro using conventional antiviral agents and supercoiled-DNA active compounds.
J Med Virol. 1990 Jun;31(2):90-7. doi: 10.1002/jmv.1890310205.
4
Inhibition of duck hepatitis B virus DNA replication by antiviral chemotherapy with ganciclovir-nalidixic acid.更昔洛韦-萘啶酸抗病毒化疗对鸭乙型肝炎病毒DNA复制的抑制作用
Antimicrob Agents Chemother. 1995 Feb;39(2):556-8. doi: 10.1128/AAC.39.2.556.
5
Reversion of duck hepatitis B virus DNA replication in vivo following cessation of treatment with the nucleoside analogue ganciclovir.核苷类似物更昔洛韦治疗停止后鸭乙型肝炎病毒DNA复制在体内的逆转
Antiviral Res. 1995 May;27(1-2):171-8. doi: 10.1016/0166-3542(94)00081-i.
6
The use of ampligen alone and in combination with ganciclovir and coumermycin A1 for the treatment of ducks congenitally-infected with duck hepatitis B virus.单独使用氨普立明以及联合使用更昔洛韦和香豆霉素A1治疗先天性感染鸭乙型肝炎病毒的鸭子。
Antiviral Res. 1993 Jun;21(2):155-71. doi: 10.1016/0166-3542(93)90051-j.
7
In vitro antiviral activity of penciclovir, a novel purine nucleoside, against duck hepatitis B virus.新型嘌呤核苷喷昔洛韦对鸭乙型肝炎病毒的体外抗病毒活性
Antimicrob Agents Chemother. 1994 Apr;38(4):719-23. doi: 10.1128/AAC.38.4.719.
8
Alterations in intrahepatic expression of duck hepatitis B viral markers with ganciclovir chemotherapy.更昔洛韦化疗对鸭乙型肝炎病毒标志物肝内表达的影响
Liver. 1994 Aug;14(4):182-92. doi: 10.1111/j.1600-0676.1994.tb00072.x.
9
10
2',3'-dideoxy-beta-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo.2',3'-二脱氧-β-L-5-氟胞苷在体外和体内均能抑制鸭乙型肝炎病毒逆转录并抑制肝细胞中的病毒DNA合成。
Antimicrob Agents Chemother. 1996 Feb;40(2):448-53. doi: 10.1128/AAC.40.2.448.
引用本文的文献
1
The Inaugural Australian Centre for Hepatitis Virology Public Panel Discussion on Viral Hepatitis Research-Lessons in Scientific Community Outreach.澳大利亚肝炎病毒学中心首届病毒性肝炎研究公共小组讨论-科学传播的经验教训。
Viruses. 2021 Sep 15;13(9):1838. doi: 10.3390/v13091838.
2
The intracellular activation of lamivudine (3TC) and determination of 2'-deoxycytidine-5'-triphosphate (dCTP) pools in the presence and absence of various drugs in HepG2 cells.拉米夫定（3TC）在HepG2细胞中的细胞内活化以及在存在和不存在各种药物的情况下2'-脱氧胞苷-5'-三磷酸（dCTP）池的测定。
Br J Clin Pharmacol. 2000 Dec;50(6):597-604. doi: 10.1046/j.1365-2125.2000.00302.x.
3
Combination chemotherapy for hepatitis B virus: the path forward?乙型肝炎病毒的联合化疗：未来之路？
Drugs. 2000 Sep;60(3):517-31. doi: 10.2165/00003495-200060030-00001.
4
In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir.BMS-200475和洛布卡韦三磷酸盐对嗜肝DNA病毒聚合酶的体外抑制作用。
Antimicrob Agents Chemother. 1998 Dec;42(12):3200-8. doi: 10.1128/AAC.42.12.3200.
本文引用的文献
1
The guanine nucleoside analog penciclovir is active against chronic duck hepatitis B virus infection in vivo.鸟嘌呤核苷类似物喷昔洛韦在体内对慢性鸭乙型肝炎病毒感染具有活性。
Antimicrob Agents Chemother. 1996 Feb;40(2):413-18. doi: 10.1128/AAC.40.2.413.
2
Hepatic purine and pyrimidine metabolism: implications for antiviral chemotherapy of viral hepatitis.肝脏嘌呤和嘧啶代谢：对病毒性肝炎抗病毒化疗的影响。
Liver. 1995 Aug;15(4):169-84. doi: 10.1111/j.1600-0676.1995.tb00667.x.
3
Concurrent use of ganciclovir and foscarnet to treat cytomegalovirus infection in AIDS patients.同时使用更昔洛韦和膦甲酸钠治疗艾滋病患者的巨细胞病毒感染。
J Infect Dis. 1993 May;167(5):1184-8. doi: 10.1093/infdis/167.5.1184.
4
Combination antiviral therapy controls severe post-liver transplant recurrence of hepatitis B virus infection.联合抗病毒治疗可控制肝移植后乙型肝炎病毒感染的严重复发。
J Gastroenterol Hepatol. 1993 Jul-Aug;8(4):353-7. doi: 10.1111/j.1440-1746.1993.tb01527.x.
5
In vitro antiviral activity of penciclovir, a novel purine nucleoside, against duck hepatitis B virus.新型嘌呤核苷喷昔洛韦对鸭乙型肝炎病毒的体外抗病毒活性
Antimicrob Agents Chemother. 1994 Apr;38(4):719-23. doi: 10.1128/AAC.38.4.719.
6
The half-life of duck hepatitis B virus supercoiled DNA in congenitally infected primary hepatocyte cultures.
Virology. 1994 Aug 15;203(1):81-9. doi: 10.1006/viro.1994.1457.
7
Alterations in intrahepatic expression of duck hepatitis B viral markers with ganciclovir chemotherapy.更昔洛韦化疗对鸭乙型肝炎病毒标志物肝内表达的影响
Liver. 1994 Aug;14(4):182-92. doi: 10.1111/j.1600-0676.1994.tb00072.x.
8
Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action.无环鸟苷类似物以非常不同的效力抑制DNA聚合酶α、δ和ε，并且具有独特的作用机制。
Biochemistry. 1995 Feb 28;34(8):2504-10. doi: 10.1021/bi00008a014.
9
Multiple drug effect analysis with confidence interval.具有置信区间的多药效应分析
Antiviral Res. 1994 Sep;25(1):1-11. doi: 10.1016/0166-3542(94)90089-2.
10
Inhibition of duck hepatitis B virus DNA replication by antiviral chemotherapy with ganciclovir-nalidixic acid.更昔洛韦-萘啶酸抗病毒化疗对鸭乙型肝炎病毒DNA复制的抑制作用
Antimicrob Agents Chemother. 1995 Feb;39(2):556-8. doi: 10.1128/AAC.39.2.556.
Zotero 插件