• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Kinetic analysis of a general model of activation of aspartic proteinase zymogens involving a reversible inhibitor. I. Kinetic analysis.

作者信息

Muñoz-López A, Sotos-Lomas A, Arribas E, Masia-Perez J, Garcia-Molina F, García-Moreno M, Varon R

机构信息

Departamento de Química-Física, Escuela Politécnica Superior de Albacete, Universidad de Castilla-La Mancha, Albacete, Spain.

出版信息

J Enzyme Inhib Med Chem. 2007 Apr;22(2):147-55. doi: 10.1080/14756360601114601.

DOI:10.1080/14756360601114601
PMID:17518340
Abstract

Starting from a simple general reaction mechanism of activation of aspartic proteinases zymogens involving a uni- and a bimolecular simultaneous activation route and a reversible inhibition step, the time course equation of the zymogen, inhibitor and activated enzyme concentrations have been derived. Likewise, expressions for the time required for any reaction progress and the corresponding mean activation rates as well as the half-life of the global zymogen activation have been derived. An experimental design and kinetic data analysis is suggested to estimate the kinetic parameters involved in the reaction mechanism proposed.

摘要

相似文献

1
Kinetic analysis of a general model of activation of aspartic proteinase zymogens involving a reversible inhibitor. I. Kinetic analysis.
J Enzyme Inhib Med Chem. 2007 Apr;22(2):147-55. doi: 10.1080/14756360601114601.
2
Kinetic analysis of a general model of activation of aspartic proteinase zymogens involving a reversible inhibitor. II. Contribution of the uni- and bimolecular activation routes.涉及可逆抑制剂的天冬氨酸蛋白酶原激活通用模型的动力学分析。II. 单分子和双分子激活途径的贡献。
J Enzyme Inhib Med Chem. 2007 Apr;22(2):157-63. doi: 10.1080/14756360601114635.
3
Kinetic analysis of a general model of activation of aspartic proteinase zymogens.天冬氨酸蛋白酶原激活通用模型的动力学分析
J Theor Biol. 2006 Oct 7;242(3):743-54. doi: 10.1016/j.jtbi.2006.04.013. Epub 2006 May 5.
4
Novel ways to prevent proteolysis - prophytepsin and proplasmepsin II.预防蛋白水解的新方法——前噬菌体蛋白酶和前质膜蛋白酶II。
Curr Opin Struct Biol. 1999 Dec;9(6):684-9. doi: 10.1016/s0959-440x(99)00030-5.
5
Multiple functions of pro-parts of aspartic proteinase zymogens.
FEBS Lett. 1994 Apr 18;343(1):6-10. doi: 10.1016/0014-5793(94)80596-2.
6
Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.恶性疟原虫新型天冬氨酸蛋白酶酶原前质蛋白酶II的晶体结构
Nat Struct Biol. 1999 Jan;6(1):32-7. doi: 10.1038/4905.
7
Linear mixed irreversible inhibition of the autocatalytic activation of zymogens. Kinetic analysis checked by simulated progress curves.酶原自催化激活的线性混合不可逆抑制。通过模拟进程曲线进行动力学分析。
Int J Biochem Cell Biol. 2002 Apr;34(4):358-69. doi: 10.1016/s1357-2725(01)00135-2.
8
Kinetics of an autocatalytic zymogen reaction in the presence of an inhibitor coupled to a monitoring reaction.在存在与监测反应偶联的抑制剂的情况下自催化酶原反应的动力学
Bull Math Biol. 1996 Jan;58(1):19-41. doi: 10.1007/BF02458280.
9
Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors.天冬氨酸蛋白酶原和病毒3C蛋白酶前体激活途径的结构方面
Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):10968-75. doi: 10.1073/pnas.96.20.10968.
10
Competitive and uncompetitive inhibitors simultaneously acting on an autocatalytic zymogen activation reaction.竞争性和非竞争性抑制剂同时作用于自催化酶原激活反应。
J Enzyme Inhib Med Chem. 2006 Dec;21(6):635-45. doi: 10.1080/14756360600858562.