Pomianek Megan E, Semmelhack M F
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
ACS Chem Biol. 2007 May 22;2(5):293-5. doi: 10.1021/cb700098c.
Small-molecule agonists and antagonists of bacterial quorum sensing can enhance our understanding of this form of cell-cell communication. A recent effort has discovered effective modulators of the autoinducer-1 circuit for bacterial quorum sensing by the synthesis and evaluation of a small library of aryl-substituted acyl-homoserine lactone analogues. This series highlights the sensitivity to structure of the contrasting responses of agonism and antagonism of the natural signal and identifies an analogue that provokes the same response as the natural signal but at 10-fold lower concentration, a "superagonist".
细菌群体感应的小分子激动剂和拮抗剂能够增进我们对这种细胞间通讯形式的理解。最近的一项研究通过合成和评估一个小的芳基取代酰基高丝氨酸内酯类似物文库，发现了用于细菌群体感应的自诱导物-1 回路的有效调节剂。该系列研究突出了天然信号激动作用和拮抗作用的对比反应对结构的敏感性，并鉴定出一种类似物，它能引发与天然信号相同的反应，但浓度低10倍，即“超级激动剂”。
