Ren Yong, Wang Guowei, Huang Junlian
Key Laboratory of Molecular Engineering of Polymers, State Education Ministry of China, Department of Macromolecular Science, Fudan University, Shanghai 200433, China.
Biomacromolecules. 2007 Jun;8(6):1873-80. doi: 10.1021/bm0701797. Epub 2007 May 23.
A convenient approach is provided to prepare liquid-core nanocapsules by cross-linking an amphiphilic copolymer at an oil-water interface. The hydrophilic copolymer poly[(ethylene oxide)-co-glycidol] was prepared by anionic polymerization of ethylene oxide and ethoxyethyl glycidyl ether first, then the hydroxyl groups on the backbone were recovered after hydrolysis and partly modified by hydrophobic conjugated linoleic acid. The copolymer with multiple linoleate pendants was absorbed at an oil-water interface and then cross-linked to form stable nanocapsules. The mean diameter of the nanocapsule was below 350 nm, and the size distribution was relatively narrow (<0.2) at low concentrations of oil in acetone (<10 mg/mL). The particle size could be tuned easily by variation of the emulsification conditions. The nanocapsule was stable in water for at least 5 months, and the shell maintained its integrity after removal of the oily core by solvent. Pyrene was encapsulated in these nanocapsules, and a loading efficiency as high as 94% was measured by UV spectroscopy.
通过在油水界面交联两亲共聚物，提供了一种制备液芯纳米胶囊的简便方法。首先通过环氧乙烷和乙氧基乙基缩水甘油醚的阴离子聚合制备亲水性共聚物聚（环氧乙烷）-共-缩水甘油，然后水解后回收主链上的羟基，并用疏水性共轭亚油酸进行部分改性。具有多个亚油酸酯侧链的共聚物在油水界面吸附，然后交联形成稳定的纳米胶囊。纳米胶囊的平均直径低于350nm，在丙酮中油浓度较低（<10mg/mL）时，尺寸分布相对较窄（<0.2）。通过改变乳化条件可以轻松调节粒径。纳米胶囊在水中至少稳定5个月，通过溶剂去除油芯后，壳层保持其完整性。芘被封装在这些纳米胶囊中，通过紫外光谱法测得的负载效率高达94%。
