Rodeck Ulrich, Fertala Andrzej, Uitto Jouni
Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Exp Dermatol. 2007 Jun;16(6):465-7. doi: 10.1111/j.1600-0625.2007.00563.x.
Squamous cell carcinomas in patients suffering from recessive dystrophic epidermolysis bullosa are highly invasive and frequently metastatic. Expression of a collagen VII fragment (NC1) has been described as a prerequisite for the development of this tumor form. This commentary focuses on potential molecular mechanisms by which expression of the NC1 fragment may augment anchorage-independent growth and survival of malignant keratinocytes.
患有隐性营养不良性大疱性表皮松解症的患者发生的鳞状细胞癌具有高度侵袭性且常发生转移。胶原VII片段（NC1）的表达被认为是这种肿瘤形成的先决条件。本评论聚焦于NC1片段的表达可能增强恶性角质形成细胞非锚定依赖性生长和存活的潜在分子机制。
