Centre For Oncology and Molecular Medicine, Ninewell's Hospital and Medical School, Dundee, DD1 9SY, UK.
Dermatol Clin. 2010 Jan;28(1):171-8. doi: 10.1016/j.det.2009.10.023.
Patients with recessive dystrophic epidermolysis bullosa develop numerous life-threatening skin cancers. The reasons for this remain unclear. Parallels exist with other scarring skin conditions, such as Marjolin ulcer. We summarize observational and experimental data and discuss proposed theories for the development of such aggressive skin cancers. A context-driven situation seems to be emerging, but more focused research is required to elucidate the pathogenesis of epidermolysis bullosa-associated squamous cell carcinoma.
隐性营养不良型大疱性表皮松解症患者会罹患许多危及生命的皮肤癌。其原因尚不清楚。这与其他瘢痕性皮肤病（如 Marjolin 溃疡）存在相似之处。我们总结了观察性和实验性数据，并讨论了此类侵袭性皮肤癌发展的理论假说。一种由环境驱动的情况似乎正在出现，但需要更集中的研究来阐明与大疱性表皮松解症相关的鳞状细胞癌的发病机制。
