Bangalore Sripal, Shahane Anupama, Parkar Sanobar, Messerli Franz H
Hypertension Program, Division of Cardiology, Columbia University College of Physicians and Surgeons, St. Luke's-Roosevelt Hospital Center, 1000 Tenth Avenue, Suite 3B-30, New York, NY 10025, USA.
Curr Hypertens Rep. 2007 Jun;9(3):184-9. doi: 10.1007/s11906-007-0033-3.
Despite data on the importance of blood pressure control in preventing cardiovascular and cerebrovascular events, only 34% of hypertensive patients have their blood pressure under control. The National Council on Patient Information and Education has estimated that the compliance rate is just over 30% for chronic conditions like hypertension. Polypharmacy and complex treatment regimens have been identified as important, modifiable risk factors for medication noncompliance. Fixed-dose combination regimens are attractive options because of the improved antihypertensive efficacy resulting from the dual mechanistic action of components targeting different effector mechanisms. One drug in the fixed-dose combination may negate an adverse effect of the other medication. Above all, fixed-dose combination therapy reduces pill burden and improves medication compliance, which can translate into better cardiovascular outcomes. Fixed-dose combinations should be used routinely for the management of hypertension and should also be considered when initiating therapy for patients with newly diagnosed hypertension.
尽管有数据表明血压控制在预防心脑血管事件方面很重要，但只有34%的高血压患者血压得到控制。全国患者信息与教育委员会估计，高血压等慢性病的依从率刚刚超过30%。多种药物联合使用和复杂的治疗方案已被确定为导致药物治疗不依从的重要、可改变的风险因素。固定剂量复方制剂是有吸引力的选择，因为其针对不同效应机制的成分具有双重作用机制，从而提高了降压疗效。固定剂量复方制剂中的一种药物可能会抵消另一种药物的不良反应。最重要的是，固定剂量联合治疗减轻了服药负担，提高了药物治疗依从性，这可以转化为更好的心血管结局。固定剂量复方制剂应常规用于高血压的管理，对于新诊断的高血压患者在开始治疗时也应予以考虑。
