Evans Kevin D, Tulloss Timothy A, Hall Nathan
Radiologic Sciences and Therapy, Division of the School of Allied Medical Professions and the Department of Radiology at the Ohio State University, Columbus, OH, USA.
Radiol Technol. 2007 May-Jun;78(5):361-6.
(18)FDG is used widely to enhance PET and PET-CT images. However, this radiotracer tends to be taken up by brown fat, which can lead to false-positive diagnoses. Purpose To determine which patients, areas of the body and circumstances are more likely to be associated with false-positive diagnoses due to (18)FDG uptake in brown fat.
A review of the literature was conducted on factors that contribute to false-positive diagnoses caused by (18)FDG uptake in brown fat.
Brown fat commonly is found in women and children and can be located in the supraclavicular, mediastinal, paravertebral and perirenal areas of the body. Research has shown that these areas can be sources of a false-positive diagnosis because of (18)FDG uptake. Studies also have indicated that cold climate affects the uptake of (18)FDG, contributing to false-positive results on PET-CT examinations.
This literature review should stimulate continued research into and awareness of the potential for false-positive PET findings in women and children during the winter months and in cold climates. This information is especially applicable to young female patients undergoing PET or PET-CT.
（18）氟代脱氧葡萄糖（FDG）被广泛用于增强正电子发射断层扫描（PET）和PET计算机断层扫描（PET-CT）图像。然而，这种放射性示踪剂容易被棕色脂肪摄取，这可能导致假阳性诊断。目的：确定哪些患者、身体部位和情况更有可能因棕色脂肪摄取（18）FDG而导致假阳性诊断。
对导致棕色脂肪摄取（18）FDG引起假阳性诊断的因素进行文献综述。
棕色脂肪常见于女性和儿童，可位于身体的锁骨上、纵隔、椎旁和肾周区域。研究表明，由于（18）FDG摄取，这些区域可能是假阳性诊断的来源。研究还表明，寒冷气候会影响（18）FDG的摄取，导致PET-CT检查出现假阳性结果。
这篇文献综述应促使人们继续研究并认识到在冬季和寒冷气候下，女性和儿童的PET检查结果出现假阳性的可能性。这些信息特别适用于接受PET或PET-CT检查的年轻女性患者。
