人尿中沙丁胺醇主要代谢物的分离与鉴定。
Isolation and identification of the major metabolite of albuterol in human urine.
作者信息
Lin C, Li Y, McGlotten J, Morton J B, Symchowicz S
出版信息
Drug Metab Dispos. 1977 May-Jun;5(3):234-8.
PMID:17520
Abstract
The major urinary metabolite of albuterol in man was isolated and purified by ion-exchange chromatography and countercurrent distribution. On the basis of proton magnetic resonance, infrared, and mass-spectral analysis, enzymic hydrolysis, and assay of inorganic sulfate after acid hydrolysis, the metabolite has been identified as the 4'-O-sulfate ester of albuterol.
摘要
沙丁胺醇在人体中的主要尿液代谢物通过离子交换色谱法和逆流分配法进行分离和纯化。基于质子磁共振、红外光谱和质谱分析、酶促水解以及酸水解后无机硫酸盐的测定，该代谢物已被鉴定为沙丁胺醇的4'-O-硫酸酯。
Zotero 插件