他汀类药物在自身免疫性疾病治疗中的有益作用。

The beneficial effects of statins in autoimmune disease therapy.

作者信息

Marai Ibrahim, Shoenfeld Yehuda

机构信息

Heart Institute, Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Israel.

出版信息

Drug News Perspect. 2007 Apr;20(3):165-9. doi: 10.1358/dnp.2007.20.3.1092097.

DOI:10.1358/dnp.2007.20.3.1092097

PMID:17520093

Abstract

Statins, HMG-CoA reductase inhibitors, are widely used for the treatment of hypercholesterolemia and the prevention of cardiovascular diseases. Recent experimental and clinical studies evaluated the effect of statins on immune and inflammatory cells, and the efficacy of statins in treatment of immune diseases. This review discusses the roles of statins in the treatment of immune and inflammatory diseases.

摘要

他汀类药物，即HMG-CoA还原酶抑制剂，被广泛用于治疗高胆固醇血症和预防心血管疾病。最近的实验和临床研究评估了他汀类药物对免疫和炎症细胞的影响，以及他汀类药物在治疗免疫疾病方面的疗效。这篇综述讨论了他汀类药物在治疗免疫和炎症性疾病中的作用。