用于肽合成的“O-酰基异肽法”：四十种“O-酰基异二肽单元”Boc-Ser/Thr(Fmoc-Xaa)-OH的合成。
"O-acyl isopeptide method" for peptide synthesis: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH.
作者信息
Yoshiya Taku, Taniguchi Atsuhiko, Sohma Youhei, Fukao Fukue, Nakamura Setsuko, Abe Naoko, Ito Nui, Skwarczynski Mariusz, Kimura Tooru, Hayashi Yoshio, Kiso Yoshiaki
机构信息
Department of Medicinal Chemistry, Center for frontier Research in Medicinal Science, 21st Century COE program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
出版信息
Org Biomol Chem. 2007 Jun 7;5(11):1720-30. doi: 10.1039/b702284k. Epub 2007 Apr 25.
The O-acyl isopeptide method has recently received attention as an efficient synthetic method for peptides. Herein, forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH (1-40) were effectively synthesized in two-steps without epimerization. The O-acyl isodipeptide units are important building blocks to enable the routine use of the O-acyl isopeptide method.
O-酰基异肽法作为一种高效的肽合成方法，最近受到了关注。在此，四十种“O-酰基异二肽单元”Boc-Ser/Thr(Fmoc-Xaa)-OH(1-40)通过两步法有效合成，且无差向异构化。O-酰基异二肽单元是使O-酰基异肽法得以常规应用的重要构件。
Zotero 插件