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心包炎：甲氨蝶呤治疗的一种罕见并发症。

Pericarditis: a rare complication of methotrexate therapy.

作者信息

Mohyuddin Tayyab, Elyan Mazen, Kushner Irving

机构信息

MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.

出版信息

Clin Rheumatol. 2007 Dec;26(12):2157-2158. doi: 10.1007/s10067-007-0630-1. Epub 2007 May 23.

DOI:10.1007/s10067-007-0630-1
PMID:17520171
Abstract

Serositis is a rare complication of methotrexate (MTX) administration. We report a 60-year-old man with rheumatoid arthritis who developed pericarditis after taking his weekly MTX dose, which recurred within hours after 2 subsequent weekly MTX doses. Pericarditis has not recurred after discontinuance of MTX over 3 years ago. We conclude that he had MTX-induced pericarditis, based on the close temporal relationship between MTX ingestion and manifestations of pericarditis on three distinct occasions because of the previous reports of MTX-induced pericarditis and because pericarditis has not recurred after MTX withdrawal.

摘要

浆膜炎是甲氨蝶呤（MTX）治疗的一种罕见并发症。我们报告一名60岁类风湿关节炎男性患者，在服用每周剂量的MTX后发生心包炎，在随后2次每周MTX剂量服用后数小时内复发。3年多前停用MTX后心包炎未再复发。基于MTX摄入与心包炎表现之间在3个不同场合的密切时间关系、既往MTX诱发心包炎的报道以及MTX停药后心包炎未再复发，我们得出结论，他患有MTX诱发的心包炎。

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Serosal complications of single-agent low-dose methotrexate used in gestational trophoblastic diseases: first reported case of methotrexate-induced peritonitis.单药低剂量甲氨蝶呤用于妊娠滋养细胞疾病的浆膜并发症：首例甲氨蝶呤诱发的腹膜炎报道病例。
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