胰腺导管内乳头状黏液性肿瘤的分子遗传学
Molecular genetics of intraductal papillary-mucinous neoplasms of the pancreas.
作者信息
Furukawa Toru
机构信息
International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Tokyo 162-8666, Japan.
出版信息
J Hepatobiliary Pancreat Surg. 2007;14(3):233-7. doi: 10.1007/s00534-006-1167-4. Epub 2007 May 29.
Intraductal papillary-mucinous neoplasms of the pancreas show characteristic clinicopathological and molecular pathobiological features which are distinct from those of conventional ductal adenocarcinomas. Alterations of KRAS, AKT/PKB, CDKN2A, TP53, SMAD4, STK11/LKB1, and DUSP6, and other molecular alterations, including global expression studies as well as their clinical implications, are discussed.
胰腺导管内乳头状黏液性肿瘤具有独特的临床病理和分子病理生物学特征，与传统导管腺癌不同。文中讨论了KRAS、AKT/PKB、CDKN2A、TP53、SMAD4、STK11/LKB1和DUSP6的改变，以及其他分子改变，包括整体表达研究及其临床意义。
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