Fukushima Noriyoshi, Fukayama Masashi
Department of Pathology, University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.
J Hepatobiliary Pancreat Surg. 2007;14(3):238-42. doi: 10.1007/s00534-006-1168-3. Epub 2007 May 29.
Mucinous cystic neoplasm (MCN) of the pancreas is a distinct clinicopathological entity characterized by mucin-producing epithelial and cyst-forming neoplasm with "ovarian-type" stroma beneath the epithelial component. It is clearly distinguished from ductal adenocarcinoma and intraductal papillary mucinous neoplasm (IPMN). However, MCN can progress to infiltrating carcinoma, and frequently shows a similar histological pattern to ductal adenocarcinoma. Several genetic alterations such as K-ras oncogene mutation, and epigenetic alterations such as hypermethylation of p16 in the invasive component of MCN are also common with ductal adenocarcinoma. Furthermore, recent technologies, including a laser-assisted microdissection system for histological slides and global gene expression profilings using DNA microarrays, made possible to identify more information about molecular abnormalities of MCNs. It is important to diagnose the lesions before they progress to an invasive carcinoma. MCN is one of the precursors of invasive pancreatic carcinoma.
胰腺黏液性囊性肿瘤（MCN）是一种独特的临床病理实体，其特征为产生黏液的上皮细胞和形成囊肿的肿瘤，并在上皮成分下方伴有“卵巢型”间质。它与导管腺癌和导管内乳头状黏液性肿瘤（IPMN）有明显区别。然而，MCN可进展为浸润性癌，且常表现出与导管腺癌相似的组织学模式。MCN浸润成分中的一些基因改变，如K-ras癌基因突变，以及表观遗传学改变，如p16高甲基化，也与导管腺癌常见。此外，包括用于组织学切片的激光辅助显微切割系统和使用DNA微阵列的全基因表达谱分析等最新技术，使得识别更多关于MCN分子异常的信息成为可能。在病变进展为浸润性癌之前进行诊断很重要。MCN是浸润性胰腺癌的前体之一。
