Nagata Kohji, Horinouchi Michiko, Saitou Miyuki, Higashi Michiyo, Nomoto Mitsuharu, Goto Masamichi, Yonezawa Suguru
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.
J Hepatobiliary Pancreat Surg. 2007;14(3):243-54. doi: 10.1007/s00534-006-1169-2. Epub 2007 May 29.
In this review article, we demonstrate the mucin expression profile in normal tissue, invasive ductal carcinoma (IDC), two subtypes of intraductal papillary-mucinous neoplasm (IPMN dark cell type and IPMN clear cell type), pancreatic intraepithelial neoplasia (PanIN), and mucinous cystic neoplasm (MCN) of the pancreas. In MUC1, there are various glycoforms, such as poorly glycosylated MUC1, sialylated MUC1, and fully glycosylated MUC1. IDCs showed high expression of all the glycoforms of MUC1. IPMNs dark cell type showed no expression or low expression of all the glycoforms of MUC1. IPMNs clear cell type showed low expression of poorly glycosylated MUC1, but expression of sialylated MUC1 and fully glycosylated MUC1. Expression of MUC2 was negative in IDCs, high in IPMNs dark cell type and low in IPMNs clear cell type. MUC5AC was highly expressed in IDCs, IPMNs dark cell type, and IPMNs clear cell type. MUC6 expression was higher in IPMNs clear cell type than in IDCs and IPMNs dark cell type. Our recent study demonstrated that high expression of MUC4 in IDCs is correlated with a poor outcome for patients. In PanINs, expression of both MUC5AC and MUC6 are an early event, whereas up-regulation of MUC1 is a late event. MCNs do not look as if they will show a specific mucin expression profile according to the literature review.
在这篇综述文章中，我们展示了胰腺正常组织、浸润性导管癌（IDC）、导管内乳头状黏液性肿瘤的两种亚型（IPMN暗细胞型和IPMN透明细胞型）、胰腺上皮内瘤变（PanIN）和黏液性囊性肿瘤（MCN）中的黏蛋白表达谱。在MUC1中，存在多种糖型，如低聚糖基化的MUC1、唾液酸化的MUC1和完全糖基化的MUC1。IDC显示出MUC1所有糖型的高表达。IPMN暗细胞型显示MUC1所有糖型均无表达或低表达。IPMN透明细胞型显示低聚糖基化的MUC1低表达，但唾液酸化的MUC1和完全糖基化的MUC1有表达。MUC2在IDC中表达为阴性，在IPMN暗细胞型中高表达，在IPMN透明细胞型中低表达。MUC5AC在IDC、IPMN暗细胞型和IPMN透明细胞型中高表达。MUC6在IPMN透明细胞型中的表达高于IDC和IPMN暗细胞型。我们最近的研究表明，IDC中MUC4的高表达与患者的不良预后相关。在PanIN中，MUC5AC和MUC6的表达都是早期事件，而MUC1的上调是晚期事件。根据文献综述，MCN似乎不会表现出特定的黏蛋白表达谱。
