Suda Koichi, Takase Masaru, Fukumura Yuki, Kashiwagi Satoko
Department of Human Pathology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
J Gastroenterol. 2007 May;42 Suppl 18:22-7. doi: 10.1007/s00535-007-2047-7.
The most frequently recognized presentation of autoimmune pancreatitis (AIP) is that mimicking pancreatic cancer. It is also known that at some stage during the disease process chronic pancreatitis clinically presents as a tumorous swelling, often suspected of being a carcinoma. In Japan, this stage has also been proposed clinically to be tumor-forming pancreatitis. Hence, tumor-forming pancreatitis shows at least two distinct types: a reparative process for centriductal acute inflammation with a background of chronic pancreatitis, which is considered to have given rise to the tumor at some stage of chronic pancreatitis, and a lymphoplasmacytic infiltration with lymphoid and fibrous proliferation in normal pancreatic tissue, which corresponds to autoimmune pancreatitis. These tumorous lesions may be changeable along the disease process.
自身免疫性胰腺炎（AIP）最常见的表现是类似胰腺癌。众所周知，在疾病过程的某些阶段，慢性胰腺炎在临床上表现为肿瘤样肿大，常被怀疑为癌。在日本，这一阶段在临床上也被称为肿瘤形成性胰腺炎。因此，肿瘤形成性胰腺炎至少表现为两种不同类型：一种是在慢性胰腺炎背景下，中央导管急性炎症的修复过程，被认为在慢性胰腺炎的某个阶段引发了肿瘤；另一种是正常胰腺组织中伴有淋巴细胞和纤维组织增生的淋巴浆细胞浸润，这与自身免疫性胰腺炎相对应。这些肿瘤性病变可能会随着疾病进程而变化。
