Cruz Boris A, Reis Dorothy D, Araujo Célia Aparecida A
Department of Rheumatology, Biocor Instituto, Nova Lima, Brazil.
Rheumatol Int. 2007 Oct;27(12):1181-3. doi: 10.1007/s00296-007-0359-9. Epub 2007 May 23.
Sarcoidosis is a chronic disease of unknown etiology characterized by granulomatous infiltration of several organs. Up to two- thirds of patients develop ocular inflammation eventually leading to significant visual loss. Treatment includes corticosteroids and immunosuppressive agents, but refractory cases do occur. In this report, the authors describe two patients with multi-systemic sarcoidosis and refractory retinal vasculitis who experienced an excellent response to infliximab. This report emphasizes the importance of TNF-alpha in the pathophysiology of this disease and warrants further studies with anti-TNF therapy in patients with refractory ocular sarcoidosis.
结节病是一种病因不明的慢性疾病，其特征为多个器官出现肉芽肿浸润。多达三分之二的患者最终会发生眼部炎症，导致严重视力丧失。治疗方法包括使用皮质类固醇和免疫抑制剂，但确实会出现难治性病例。在本报告中，作者描述了两名患有多系统结节病和难治性视网膜血管炎的患者，他们对英夫利昔单抗有极佳的反应。本报告强调了肿瘤坏死因子-α在该疾病病理生理学中的重要性，并值得对难治性眼部结节病患者进行抗TNF治疗的进一步研究。
