Hermet M, le Guenno G, Rieu V, Philippe P, Ruivard M
Service de médecine interne, hôpital Estaing, CHU de Clermont-Ferrand, Clermont-Ferrand, France.
Rev Med Interne. 2012 Jan;33(1):46-9. doi: 10.1016/j.revmed.2011.04.002. Epub 2011 May 20.
Sinonasal sarcoidosis is difficult to treat. Infliximab seems to be useful in the treatment of sarcoidosis of the upper respiratory tract.
We report three cases of sinonasal sarcoidosis in two women of 36 and 42-year-old and in a 64-year-old man. Resistance or dependence to corticosteroids and absence of efficacy of methotrexate therapy in one patient led to administer anti-TNFα therapy with infliximab. Outcome was favourable on sarcoid lesions but treatment was discontinued because of infectious complications and worsening of sarcoid chest involvement.
This case series suggests that infliximab might be useful for the treatment of sarcoidosis with sinonasal involvement.
鼻窦结节病难以治疗。英夫利昔单抗似乎对上呼吸道结节病的治疗有用。
我们报告了3例鼻窦结节病病例，分别为两名36岁和42岁的女性以及一名64岁的男性。一名患者对皮质类固醇耐药或依赖，且甲氨蝶呤治疗无效，因此给予英夫利昔单抗进行抗TNFα治疗。结节病病变的治疗效果良好，但由于感染并发症和结节病肺部受累加重，治疗中断。
该病例系列表明，英夫利昔单抗可能对治疗累及鼻窦的结节病有用。
