Kandi Basak, Cicek Demet, Ilhan Nevin
Departments of Dermatology, Faculty of Medicine, Firat University, Elazig, Turkey.
J Dermatolog Treat. 2007;18(2):69-75. doi: 10.1080/09546630601156355.
To determine the role of oxidative stress and the antioxidant defense mechanism in the etiopathogenesis of active and inactive Behçets disease. In line with this objective, the present study aimed to examine the levels of nitric oxide (NO) and malondialdehyde (MDA), which are the end products of oxidant stress, and vitamins, which are non-enzymatic antioxidants, for the diagnosis and particularly the follow-up of Behçet's disease.
The study group consisted of a total of 60 individuals: 40 of whom were Behçet's disease patients and 20 were healthy individuals. Of the 40 Behçet's patients, 29 had the active and 11 had the inactive (stable) form of the disease.
Although plasma MDA and NO (its stable form nitrite) levels in the total patient group were statistically significantly higher than those in the control group (p<0.06), there was no statistically significant difference as such between inactive Behçet's patients and the control group (p>0.05). Vitamin E, C, B1, B2 and flavin mononucleotide (FMN) values were significantly lower in the patient group in comparison with the control group (p<0.05). There was no statistically significant difference in other vitamin values.
It is contemplated that measurement of such oxidative stress factors as MDA and NO and an accompanying evaluation of the antioxidant defense system can be significant in the diagnosis and treatment follow-up of Behçet's disease.
确定氧化应激和抗氧化防御机制在活动期和非活动期白塞病发病机制中的作用。基于这一目的，本研究旨在检测氧化应激终产物一氧化氮（NO）和丙二醛（MDA）以及非酶抗氧化剂维生素的水平，以用于白塞病的诊断，尤其是随访。
研究组共60人，其中40例为白塞病患者，20例为健康个体。40例白塞病患者中，29例为疾病活动期，11例为疾病非活动期（稳定期）。
尽管患者组血浆MDA和NO（其稳定形式亚硝酸盐）水平在统计学上显著高于对照组（p<0.06），但非活动期白塞病患者与对照组之间无统计学显著差异（p>0.05）。与对照组相比，患者组维生素E、C、B1、B2和黄素单核苷酸（FMN）值显著降低（p<0.05）。其他维生素值无统计学显著差异。
可以设想，检测MDA和NO等氧化应激因素并同时评估抗氧化防御系统对白塞病的诊断和治疗随访可能具有重要意义。
