Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, 77555-0647, USA.
Curr Med Chem. 2011;18(6):931-42. doi: 10.2174/092986711794927694.
Current understanding of the role of oxidative stress in ocular inflammatory diseases indicates that antioxidant therapy may be important to optimize the treatment. Recently investigated antioxidant therapies for ocular inflammatory diseases include various vitamins, plant products and reactive oxygen species scavengers. Oxidative stress plays a causative role in both non-infectious and infectious uveitis complications, and novel strategies to diminish tissue damage and dysfunction with antioxidant therapy may ameliorate visual complications. Preclinical studies with experimental animals and cultured cells demonstrate significant anti-inflammatory effects of a number of promising antioxidant agents. Many of these antioxidants are under clinical trial for various inflammatory diseases other than uveitis such as cardiovascular, rheumatoid arthritis and cancer. Well planned interventional clinical studies in the field of ocular inflammation will be necessary to sufficiently investigate the potential medical benefits of antioxidant therapies for uveitis. This review summarizes the recent investigations of novel antioxidant agents for ocular inflammation, with selected studies focused on uveitis.
目前对氧化应激在眼部炎症性疾病中的作用的认识表明，抗氧化治疗可能对优化治疗很重要。最近研究的眼部炎症性疾病的抗氧化治疗包括各种维生素、植物产品和活性氧清除剂。氧化应激在非传染性和传染性葡萄膜炎并发症中起因果作用，用抗氧化治疗来减少组织损伤和功能障碍的新策略可能改善视觉并发症。用实验动物和培养细胞进行的临床前研究表明，许多有前途的抗氧化剂具有显著的抗炎作用。这些抗氧化剂中的许多都在临床试验中，用于治疗除葡萄膜炎以外的各种炎症性疾病，如心血管疾病、类风湿关节炎和癌症。有必要在眼部炎症领域进行精心设计的干预性临床研究，以充分研究抗氧化治疗对葡萄膜炎的潜在医学益处。本综述总结了最近对眼部炎症的新型抗氧化剂的研究，其中一些研究集中在葡萄膜炎上。
