Aminzadeh Arya, Demircay Zeynep, Ocak Kerem, Soyletir Guner
Departments of Dermatology, Marmara University School of Medicine, Istanbul, Turkey.
J Dermatolog Treat. 2007;18(2):105-8. doi: 10.1080/09546630601165125.
Chronic furunculosis is a recurrent staphylococcal abscess of the hair follicle. Besides ensuring personal hygiene, the management consists of long-term treatment with topical and systemic antibiotics.
An open-labeled, prospective study was conducted to assess the clinical and in vitro efficacy of azithromycin in the long-term suppressive treatment of chronic furunculosis.
Patients with a history of three or more episodes of furuncles were assigned to receive 12 weeks of suppressive treatment with azithromycin at a weekly dosage of 500 mg. In vitro susceptibility of azithromycin was evaluated with E-test. The primary efficacy parameter was complete absence of furuncles during the 3 months of azithromycin treatment. The secondary efficacy parameter was further absence of furuncles during the 3-month follow-up period.
At the end of 3 months of therapy, azithromycin was found to be effective in 19 (79.2%) of 24 patients; 18 of these patients remained in remission during the 3 months of follow-up. All of the strains were methicillin-sensitive. The results of the E-test showed that 15 of 18 strains (83.3%) were susceptible to azithromycin.
The results of this study indicate that azithromycin is an effective and safe alternative in the treatment of chronic furunculosis caused by methicillin-sensitive Staphylococcus aureus.
慢性疖病是一种复发性毛囊葡萄球菌脓肿。除了确保个人卫生外，治疗方法包括长期使用局部和全身抗生素。
开展一项开放标签的前瞻性研究，以评估阿奇霉素在慢性疖病长期抑制治疗中的临床和体外疗效。
有三次或更多次疖病发作史的患者被分配接受为期12周的阿奇霉素抑制治疗，每周剂量为500毫克。用E-test评估阿奇霉素的体外敏感性。主要疗效参数是在阿奇霉素治疗的3个月期间完全没有疖病。次要疗效参数是在3个月的随访期内进一步没有疖病。
在治疗3个月末，发现24例患者中有19例（79.2%）对阿奇霉素有效；这些患者中有18例在3个月的随访期内仍处于缓解状态。所有菌株均对甲氧西林敏感。E-test结果显示，18株菌株中有15株（83.3%）对阿奇霉素敏感。
本研究结果表明，阿奇霉素是治疗由甲氧西林敏感金黄色葡萄球菌引起的慢性疖病的一种有效且安全的替代药物。
