Aschoff Roland, Wozel Gottfried
Department of Dermatology, University Hospital Carl Gustav Carus of the Technical University, Dresden, Germany.
J Dermatolog Treat. 2007;18(2):115-7. doi: 10.1080/09546630601156330.
Owing to severe itching and scratching, the natural course of lichen simplex chronicus (LSC) is clinically characterized by typical lichenoid lesions. Topical corticosteroids are often used to treat LSC but after withdrawal a relapse will sometimes occur. Therefore, LSC can be difficult to treat over time. We report a 13-year-old boy suffering from LSC on two symmetrical circumscribed areas on the temple, whose lesions healed completely with tacrolimus 0.1% ointment within approximately 9 months. During active treatment no adverse drug reaction was observed. The patient is completely free of symptoms 3 years after cessation of treatment. We conclude that topical tacrolimus can be used as an effective, long-lasting therapeutic modality in treating LSC, especially in sensitive skin areas such as the face.
由于严重瘙痒和搔抓，慢性单纯性苔藓（LSC）的自然病程在临床上以典型的苔藓样病变为特征。外用糖皮质激素常用于治疗LSC，但停药后有时会复发。因此，随着时间的推移，LSC可能难以治疗。我们报告一名13岁男孩，其双侧颞部对称的局限性区域患有LSC，使用0.1%他克莫司软膏后，皮损在约9个月内完全愈合。在积极治疗期间未观察到药物不良反应。停药3年后，患者完全无症状。我们得出结论，外用他克莫司可作为治疗LSC的一种有效、持久的治疗方式，尤其是在面部等敏感皮肤区域。
