Zhang Xibao, He Yuqing, Zhou Hua, Luo Quan, Li Changxing
Dermatological Department, Guangzhou Institute of Dermatology, Guangzhou, PR of China.
J Dermatolog Treat. 2007;18(2):118-22. doi: 10.1080/09546630601156348.
One case of keratitis ichthyosis deafness (KID) syndrome and two cases of bullous ichthyosiform erythroderma (BIE) were treated with systemic acitretin. The severe hyperkeratotic lesions improved dramatically with acitretin therapy in the KID case. Substantial improvement of the palmoplantar keratoderma was also observed. During follow-up, laboratory results remained within normal limits and no skeletal abnormalities were detected. The two cases with BIE also showed good responses to acitretin. Long-term follow-up of these cases showed that signs and symptoms were well under control and no adverse effects were noted.
1例角膜炎鱼鳞病耳聋（KID）综合征患者和2例大疱性鱼鳞病样红皮病（BIE）患者接受了阿维A全身治疗。在KID综合征患者中，阿维A治疗使严重的角化过度病变显著改善。掌跖角化病也有明显改善。随访期间，实验室检查结果保持在正常范围内，未发现骨骼异常。2例BIE患者对阿维A也有良好反应。对这些病例的长期随访表明，症状和体征得到良好控制，未观察到不良反应。
