Maskarinec Gertraud, Takata Yumie, Chen Zhao, Gram Inger Torhild, Nagata Chisato, Pagano Ian, Hayashi Kentaro, Arendell Leslie, Skeie Guri, Rinaldi Sabina, Kaaks Rudolph
Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA.
Int J Cancer. 2007 Oct 15;121(8):1786-92. doi: 10.1002/ijc.22834.
Insulin-like growth factor (IGF-I) and prolactin have been found to be associated with breast cancer risk and with mammographic density. In a pooled analysis from 4 geographic locations, we investigated the association of percent mammographic density with serum levels of IGF-I, IGFBP-3 and prolactin. The pooled data set included 1,327 pre- and postmenopausal women: Caucasians from Norway, Arizona and Hawaii, Japanese from Hawaii and Japan, Latina from Arizona, and Native Hawaiians from Hawaii. Serum samples were assayed for IGF-I, IGFBP-3 and prolactin levels using ELISA assays. Mammographic density was quantified using a computer-assisted density method. After stratification by menopausal status, multiple regression models estimated the relation between serum analytes and breast density. All serum analytes except prolactin among postmenopausal women differed significantly by location/ethnicity group. Among premenopausal subjects, IGF-I levels and the molar ratio were highest in Hawaii, intermediate in Japan and lowest in Arizona. For IGFBP-3, the order was reversed. Among postmenopausal subjects, Norwegian women had the highest IGF-I levels and women in Arizona had the lowest while women in Japan and Hawaii had intermediate levels. We observed no significant relation between percent density and IGF-I or prolactin levels among pre-and postmenopausal women. The significant differences in IGF-I levels by location but not ethnicity suggest that environmental factors influence IGF-I levels, whereas percent breast density varies more according to ethnic background than by location. Based on this analysis, the influence of circulating levels of IGF-I, IGFBP-3, and prolactin on percent density appears to be very small.
胰岛素样生长因子（IGF-I）和催乳素已被发现与乳腺癌风险及乳腺X线密度有关。在一项来自4个地理位置的汇总分析中，我们研究了乳腺X线密度百分比与血清IGF-I、IGFBP-3和催乳素水平之间的关联。汇总数据集包括1327名绝经前和绝经后女性：来自挪威、亚利桑那州和夏威夷的白种人，来自夏威夷和日本的日本人，来自亚利桑那州的拉丁裔，以及来自夏威夷的夏威夷原住民。使用酶联免疫吸附测定法（ELISA）检测血清样本中的IGF-I、IGFBP-3和催乳素水平。使用计算机辅助密度法对乳腺X线密度进行量化。在按绝经状态分层后，多元回归模型估计了血清分析物与乳腺密度之间的关系。除绝经后女性中的催乳素外，所有血清分析物在不同地理位置/种族组之间存在显著差异。在绝经前受试者中，IGF-I水平和摩尔比在夏威夷最高，在日本居中，在亚利桑那州最低。对于IGFBP-3，顺序相反。在绝经后受试者中，挪威女性的IGF-I水平最高，亚利桑那州的女性最低，而日本和夏威夷的女性水平居中。我们未观察到绝经前和绝经后女性的密度百分比与IGF-I或催乳素水平之间存在显著关系。IGF-I水平因地理位置而非种族存在显著差异，这表明环境因素影响IGF-I水平，而乳腺密度百分比根据种族背景的变化比地理位置更大。基于此分析，IGF-I、IGFBP-3和催乳素的循环水平对密度百分比的影响似乎非常小。
