Dagenais S
Issues Emerg Health Technol. 2007 May(98):1-4.
In viscosupplementation, a glycosaminoglycan called hyaluronic acid (HA) is administered via intra-articular injection to patients with osteoarthritis (OA). Two systematic reviews found that HA for hip OA may relieve pain and improve function. Randomized controlled trials had differing results. Uncontrolled studies suggest that there are moderate improvements regarding pain and function for three to six months after HA injection. There is no evidence regarding the cost-effectiveness of this therapy. No serious adverse events have been reported after intra-articular injection of HA for hip OA. The best available evidence suggests that HA may offer symptomatic relief in patients with mild to moderate hip OA for whom other conservative therapies are contraindicated or have failed. Currently, there is insufficient good quality evidence to determine this conclusively.
在粘弹性补充疗法中，一种名为透明质酸（HA）的糖胺聚糖通过关节内注射给予骨关节炎（OA）患者。两项系统评价发现，用于髋骨关节炎的透明质酸可能缓解疼痛并改善功能。随机对照试验结果各异。非对照研究表明，透明质酸注射后三到六个月，疼痛和功能有中度改善。尚无关于该疗法成本效益的证据。关节内注射透明质酸治疗髋骨关节炎后，未报告严重不良事件。现有最佳证据表明，对于其他保守治疗方法禁忌或无效的轻至中度髋骨关节炎患者，透明质酸可能缓解症状。目前，尚无足够的高质量证据来最终确定这一点。
