Eyigör Can, Pirim Alihan, Eyigör Sibel, Uyar Meltem
Department of Anesthesiology and Reanimation, Ege University Faculty of Medicine, İzmir, Turkey.
Agri. 2010 Oct;22(4):139-44.
Hyaluronic acid (HA) is used for intraarticular treatment of hip osteoarthritis (OA). The objective of this study was to determine the efficacy of intraarticular injection of HA through a lateral approach under fluoroscopic control for advanced hip OA.
The study included 21 patients with advanced hip OA. All patients received 2.5 ml HA injection once a week for 3 weeks by lateral approach under fluoroscopic control. Disability (Lequesne index), pain scores (visual analog scale-VAS) and analgesic use of patients were assessed before treatment and 1, 3 and 6 months after the treatment.
Lequesne index and VAS pain scores measured 1, 3 and 6 months after treatment were significantly lower compared to baseline scores (p<0.001). Although analgesic use was significantly reduced 1 and 3 months after treatment compared to baseline (p<0.05), no difference was determined in analgesic use at the 6th month (p>0.05). No side effect was observed.
In conclusion, intraarticular HA injection through a lateral approach under fluoroscopic control was shown to be a safe and effective method for patients with advanced hip OA.
透明质酸（HA）用于髋关节骨关节炎（OA）的关节腔内治疗。本研究的目的是确定在透视控制下经外侧入路关节腔内注射HA治疗晚期髋关节OA的疗效。
本研究纳入21例晚期髋关节OA患者。所有患者在透视控制下经外侧入路每周注射1次2.5ml HA，共注射3周。在治疗前以及治疗后1、3和6个月评估患者的功能障碍（Lequesne指数）、疼痛评分（视觉模拟量表-VAS）和镇痛药物使用情况。
治疗后1、3和6个月测得的Lequesne指数和VAS疼痛评分与基线评分相比显著降低（p<0.001）。虽然治疗后1和3个月与基线相比镇痛药物使用显著减少（p<0.05），但在第6个月时镇痛药物使用情况无差异（p>0.05）。未观察到副作用。
总之，在透视控制下经外侧入路关节腔内注射HA对晚期髋关节OA患者是一种安全有效的方法。
