Meyer J R, Shulkin B L
Department of Radiology, University of Michigan Medical Center, Ann Arbor.
Clin Nucl Med. 1991 Nov;16(11):807-9. doi: 10.1097/00003072-199111000-00001.
A 3 1/2-year-old boy had thigh pain and a leg mass. Bone scanning demonstrated intense uptake within the involved femur, but no uptake within the soft tissues or evidence of metastatic spread. Radiographs and CT scanning showed a large soft tissue mass and periosteal reaction suggestive of Ewing's sarcoma. Following chemotherapy, the patient had an apparently good clinical response. However, bone scanning showed uptake that was more intense and extensive than it was before therapy. Plain films and CT showed that the uptake was evidence of soft tissue calcification and that the mass had shrunk. This is an unusual example of the flare response to therapy because the apparent progression of the disease on bone scanning was caused by extraskeletal uptake.
一名3岁半的男孩出现大腿疼痛和腿部肿块。骨扫描显示受累股骨内有强烈摄取，但软组织内无摄取，也无转移扩散迹象。X线片和CT扫描显示一个大的软组织肿块和骨膜反应，提示尤因肉瘤。化疗后，患者临床反应明显良好。然而，骨扫描显示摄取比治疗前更强烈、更广泛。平片和CT显示摄取是软组织钙化的证据，且肿块已缩小。这是治疗后耀斑反应的一个不寻常例子，因为骨扫描上疾病的明显进展是由骨骼外摄取引起的。
