Gorgun O V, Portianko A S
Klin Med (Mosk). 2007;85(2):70-2.
Collagenous sprue (CS) is a rare disease of the small bowel, which is characterized by complete atrophy of mucosal villi and excessive subepithelial collagen deposition. The authors describe a 40-year-old patient, who was examined for severe malabsorption syndrome. The diagnosis of celiac disease was based upon serological and histological data, but gluten-free diet was not effective and only treatment with prednisolone led to positive changes. Another histologic study revealed a focal deposit of collagen under the epithelium in addition to signs of intestinal mucosal atrophy, and the diagnosis of CS was made. The case is discussed from the positions of known information of CS.
胶原性口炎性腹泻（CS）是一种罕见的小肠疾病，其特征为黏膜绒毛完全萎缩和上皮下胶原过度沉积。作者描述了一名40岁的患者，该患者因严重吸收不良综合征接受检查。乳糜泻的诊断基于血清学和组织学数据，但无麸质饮食无效，仅使用泼尼松龙治疗才导致出现积极变化。另一项组织学研究显示，除了肠黏膜萎缩的迹象外，上皮下还有局灶性胶原沉积，从而做出了CS的诊断。本文从CS的已知信息角度对该病例进行了讨论。
