van der Linden Jacqueline C, Weinans Harrie
Erasmus MC, Department of Orthopaedics, 3000 DR Rotterdam, The Netherlands.
Curr Osteoporos Rep. 2007 Jun;5(2):56-61. doi: 10.1007/s11914-007-0003-3.
Bone strength and stiffness depend strongly on bone mass, but they also depend on the microarchitecture and tissue quality of both cancellous and cortical bone. All these aspects differ between individuals and between anatomic sites. This review discusses ways to characterize the three-dimensional cancellous architecture as well as changes in architecture and bone composition caused by bone remodeling. The methods used range from detailed descriptions of sizes and distances in cancellous bone to coarser texture analysis methods using clinical data. As the resolution of clinical images increases, it may become possible to use knowledge of the relationship between bone microarchitecture and strength to predict fracture risk clinically.
骨强度和刚度在很大程度上取决于骨量，但它们也取决于松质骨和皮质骨的微观结构及组织质量。所有这些方面在个体之间以及不同解剖部位之间都存在差异。本综述讨论了表征三维松质骨结构的方法，以及骨重塑引起的结构和骨成分变化。所使用的方法从对松质骨大小和距离的详细描述到使用临床数据的更粗略的纹理分析方法。随着临床图像分辨率的提高，利用骨微观结构与强度之间关系的知识在临床上预测骨折风险可能成为现实。
