用商业抗钩端螺旋体多价全细菌疫苗评估猪初乳免疫。

Evaluation of colostral immunity in swine with commercial anti-leptospira polyvalent whole-bacteria vaccine.

作者信息

Martins Soto Francisco Rafael, Regina Pinheiro Sônia, Honma Ito Fumio, Maria Moraes Zenaide, Paldes Gonçales Amane, Santos de Azevedo Sérgio, Bernardi Fernanda, Rodrigues Camargo Sebastião, Arruda Vasconcellos Silvio

机构信息

Center for Sanitary Surveillance and Zoonoses Control "Tereza Rodrigues de Camargo", Estrada da Vargem do Salto, Km 4,5, Bairro dos Paes, CEP 18150-000, Ibiúna, SP, Brazil.

出版信息

Comp Immunol Microbiol Infect Dis. 2008 Jul;31(4):327-35. doi: 10.1016/j.cimid.2007.03.002. Epub 2007 May 22.

DOI:10.1016/j.cimid.2007.03.002

PMID:17521726

Abstract

The intensity and duration of passive immunity against swine leptospirosis were investigated by the microscopic agglutination test and in vitro leptospira growth inhibition. Twenty-one females at first parturition were divided into three groups: Group A (n=08): received two doses with 30 days interval of the commercial anti-leptospira bacterin A. Group B (n=06) received two doses with 30 days interval of the commercial anti-leptospira bacterin B and Group C (n=07) was the control. In all groups the colostrums were collected. Blood collection of piglets was performed in four different ages. Agglutinin antibodies were equally detected in sera and colostrums for serovars Canicola, Grippotyphosa, Copenhageni, Icterohaemorrhagiae and Pomona (Group A) and Canicola, Copenhageni, Icterohaemorrhagiae, Pomona and Hardjo (Group B). Mean neutralizing antibodies titers were low. Passive immunity was low duration.

摘要

通过显微镜凝集试验和体外钩端螺旋体生长抑制试验，研究了猪钩端螺旋体病被动免疫的强度和持续时间。21头初产母猪分为三组：A组（n = 8）：间隔30天接种两剂商业抗钩端螺旋体菌苗A。B组（n = 6）间隔30天接种两剂商业抗钩端螺旋体菌苗B，C组（n = 7）为对照组。收集所有组的初乳。在四个不同年龄段采集仔猪血液。在血清和初乳中均检测到针对犬型、波摩那型、哥本哈根型、出血性黄疸型和波摩那型（A组）以及犬型、哥本哈根型、出血性黄疸型、波摩那型和哈焦型（B组）血清型的凝集素抗体。平均中和抗体滴度较低。被动免疫持续时间较短。