Karthikeyan Mari Sithambaram, Prasad Dasappa Jagadeesh, Mahalinga Manjathuru, Holla Bantwal Shivarama, Kumari Nalilu Suchetha
Department of Chemistry, Mangalore University, Mangalagangothri, Mangalore, Karnataka 574199, India.
Eur J Med Chem. 2008 Jan;43(1):25-31. doi: 10.1016/j.ejmech.2007.03.013. Epub 2007 Apr 3.
A series of 2,4-dichloro-5-fluorophenyl containing 1,3,4-oxadiazoles (10 and 11) were synthesized by POCl3 cyclization of 2,4-dichloro-5-fluorobenzoyl hydrazide (4) and 2-(2,4-dichloro-5-fluorophenyl)cinchoninyl hydrazide (8) with aryloxyacetic acids (9). The structures of newly synthesized compounds were characterized by spectral and elemental analyses. All the compounds were screened for their antibacterial and antifungal activities. Compounds 10a, 10d and 11g showed very good antimicrobial activity. Compound 10d showed good bactericidal and fungicidal activities.
通过2,4-二氯-5-氟苯甲酰肼（4）和2-(2,4-二氯-5-氟苯基)辛可宁酰肼（8）与芳氧基乙酸（9）进行POCl₃环化反应，合成了一系列含2,4-二氯-5-氟苯基的1,3,4-恶二唑（10和11）。通过光谱和元素分析对新合成化合物的结构进行了表征。对所有化合物进行了抗菌和抗真菌活性筛选。化合物10a、10d和11g表现出非常好的抗菌活性。化合物10d表现出良好的杀菌和杀真菌活性。
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